Can glycohemoglobin be used to assess glycemic control in patients with chronic renal failure?

false-positive results in S. pneumoniae cases because only the amount of CDT (a-to di-or trisialotransferrin) and/or the CDT/transferrin ratio is determined (19). HUS associated with S. pneumoniae therefore has to be considered in the diagnosis of primary and secondary defects in the glycan part of N-glycoproteins. The non-S. pneumoniae-associated HUS cases showed normal isoform distribution in both glycoproteins investigated in this study. This means that IEF of plasma transferrin distinguishes between S. pneumoniae-associated HUS and the two other HUS forms. This technique may therefore be complementary to the conventional bacteriologic techniques that are available for this purpose and may help to avoid the use of blood transfusions which would be life-threatening in cases of HUS associated with a S. pneumoniae infection. Eggermont E, et al. Familial psychomotor retardation with markedly fluctuating serum prolactin, FSH and GH levels, partial TBG deficiency, increased arylsulphatase A and increased CSF protein: a new syndrome? Pediatr Res 1980;14:179. 2. Stibler H, Jaeken J. Carbohydrate deficient serum transferrin in a new systemic hereditary syndrome. Carbohydrate deficient glycoprotein syndrome Type Ib. Phosphomannose isomerase deficiency and mannose therapy. A novel carbohydrate-deficient glycoprotein syndrome characterised by a deficiency in glucosylation of the dolichol-linked oligosaccharide. Deficiency of dolichol-phosphate-mannose synthase-1 causes congenital disorder of glycosylation type Ie.drate deficient glycoprotein syndrome type II: a deficiency in Golgi localised N-acetyl-glucosaminyltransferase II. alterations of serum glycoproteins in alcoholic and cirrhotic patients revealed by high resolution two dimensional gel electrophoresis. of phosphomannose isomerase by fructose-1-phosphate: an explanation for defective N-glycosylation in hereditary fructose intolerance.coccus pneumonia-induced haemolytic uremic syndrome: a case for early diagnosis. Detachment of endothelium and epithelium from the glomerular basement membrane produced by kidney perfusion with neuraminidase. Investigation by isoelectric focusing of the initial carbohydrate-deficient transferrin (CDT) and non-CDT transferrin isoform fractionation step involved in determination of CDT by the ChronAlcol. Many factors can affect interpretation of glycohemoglobin (GHB/HbA1c) measurements in patients with chronic renal failure (CRF). Several reports have suggested that erythrocyte survival is substantially lowered in most patients with CRF; this would be expected to lower GHB results (1– 6). Several reports have also suggested that GHB methods, especially those based on charge separation (e.g., ion-exchange HPLC), may have interference by carbamylated hemoglobin that would be expected to falsely increase GHB results (7–17). Many of these reports evaluated older assay methods; newer ion-exchange methods may show improved separation of the HbA1c fraction from other hemoglobin adducts (15, 17). Because renal failure …